The following additional requirements or limitations apply to the transport of radioactive material to, from or within the United States:

1. Radioactive material, other than that contained in excepted packagings, may not be offered for transport aboard passenger aircraft unless the radioactive material is intended for use in, or incident to, research or medical diagnosis or treatment. The transport document for the radioactive material, other than that contained in excepted packagings aboard a passenger aircraft, must contain a certification stating that the shipment contains radioactive material intended for use in, or incident to, research or medical diagnosis or treatment. Regardless of its intended use, no person may carry a Type B(M) package aboard a passenger-carrying aircraft, a vented Type B(M) package aboard any aircraft, or a liquid pyrophoric Class 7 material aboard any aircraft.

2. No person may offer for transport aboard a passenger aircraft a package or an overpack with a transport index greater than 3.0.

3. No person may offer or transport plutonium aboard an aircraft unless:

   1. the plutonium is contained in a medical device designed for individual human application;

   2. the specific activity of the material containing the plutonium is less than 1 Bq/g;

   3. the plutonium is shipped in a single package containing no more than an A₂ quantity of plutonium in any isotope or form and is shipped in accordance with applicable provisions of these Instructions for Class 7 radioactive material; or

   4. the plutonium is specifically authorized for air shipment by the appropriate authority of the U.S.

4. For a package containing radioactive material with an activity greater than:

   1. 3000 × A₁;

   2. 3000 × A₂; or

   3. 1000 TBq (27000 Ci), whichever is least,

   the notation "highway route controlled quantity" must appear on the transport document.

5. Packages containing:

   1. 3000 × A₁;

   2. 3000 × A₂; or

   3. 1000 TBq (27000 Ci), whichever is least,

   must bear the Radioactive material, Class 7, Category III - Yellow label.

6. All Type B(U), Type B(M), Type H(U), Type H(M) and fissile package designs must be certified by the U.S. Department of Transportation. Individual packages with a criticality safety index exceeding 50, and shipments of packages with a total criticality safety index greater than 50 on passenger aircraft and 100 on cargo aircraft, may not be transported to, from or within the United States aboard a passenger or cargo aircraft without the prior approval of the appropriate authority of the United States (see US 1). Requests for package design certification and approvals should be directed to the appropriate authority of the U.S., Attention: Radioactive Materials Branch (PHH-23).

7. Except for low specific activity material and surface contaminated objects, activity limits for Type A and Type B packages shall be limited in accordance with 49 CFR 173.431.